Clinical research and case study

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Vitiligo is being tackled by multipronged attacks in the form of advancement in basic research, genetics and treatment including surgical management. Vitiligo Global Issues Consensus Conference (VGICC) recently revised the classification of the disease. Recent progress in genetics of generalized vitiligo provides insights into underlying pathogenic mechanisms and incrimination of vitiligo susceptibility genes that controls important aspects of immune regulation. Vitiligo is a T-cell mediated autoimmune disease. Heat shock protein 70 (HSP70) plays a central non redundant role in precipitating of depigmentation in vitiligo.Mosenson et al. in a very promising study recently showed that vitiligo can be reversed through immune targeting with mutant HSP70.